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In a different multicenter, randomized, double-blind, placebo-controlled trial, Ziegler and co-workers examined the effects of ALA on neuropathic deficits and positive sensory symptoms in patients with diabetes with distal symmetric polyneuropathy [76]

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Excessive pyroptosis leads to rapid rupture of the plasma membrane and the excessive release of proinflammatory cytokines and chemokines, which results in neuroinflammation that triggers a cascade of secondary injuries culminating in neuronal death

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Pan M, Wang Z, Wang Y, Jiang X, Fan Y, Gong F, et al

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