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However, the results were difficult to interpret since the cells ruptured and the expressing nuclei were free-floating

doi:10.1038/s41467-020-17813-1

Tirzepatide, marketed for weight management as Zepbound, starts at 2.5 mg once weekly for four weeks an introductory dose meant to limit nausea, not to drive weight loss then steps up to 5 mg, and can be increased in 2.5 mg increments no sooner than every four weeks

The results showed from the biological evaluation that only three compounds 47a 47c exhibit potent inhibitory effects with IC 50 values of 12.5, 7.0 and 1.5 M (Figure 14)