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[10] Vitamin B is an essential nutrient for fetal development, and untreated B deficiency in a pregnant woman can lead to serious neurological damage in the infant

Although there are some secondary biomarkers such as the measurement of certain enzyme activities in the leukocytes or the excretion of 3-hydroxy-3-methylbutyric acid in the urine, these are ambiguous indications and only a few doctors are familiar with the corresponding tests (8, 9)

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