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6 Therapeutic opportunities targeting the ferroptosis-neuroinflammation axis As inflammation and ferroptosis are both promoters of depression and their bidirectional interaction may exacerbate the progression of depression, drugs that suppress both inflammation and ferroptosis appear to have potential antidepressant effects

In the investigator-initiated trial, patients underwent two stages of randomization using the block randomization method, with random group codes generated by SAS software version 9.4