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Glucose metabolism has been shown to modulate the effector function of T H 17 cells by controlling a metabolic-transcriptional network, with Acly serving as a key rate-limiting mediator generating acetyl-CoA and dictating T H 17 cell pathogenicity 21 , while restraining the development of FOXP3 + T regs 74

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Funding The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article

Sci Transl Med 5:178ra140178ra140 Garcia-Romo GS, Caielli S, Vega B, Connolly J, Allantaz F, Xu Z, Punaro M, Baisch J, Guiducci C, Coffman RL (2011) Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus

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