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Urate, also known as uric acid, is a major endogenous antioxidant that is neuroprotective against both astrocyte-induced toxicity in SOD1 G93A mice and H 2 O 2 induced oxidative stress in cells expressing mutant SOD1 G93A (Bakshi et al., G85R cellular and Drosophila models (Zhang et al., 2019b)

The brain and adrenal glands have the highest concentrations of vitamin C at 15 to 50 times higher than those found in the blood

Given this variability, a conservative approach is wise: assume the shorter end of the spectrum and store as best as possible

Specifically excessive intervertebral elevation with lateral lumbar interbody fusion (LLIF) increased the adjacent segment disease (ASD)

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