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Chem Res Toxicol 24:3034 Acknowledgments This work was founded by FCTFundao para a Cincia e a Tecnologia and by Fundao BPI La Caixa, within call POCI-01-0145-FEDER-031309 and project titled AquaeVitae - gua Termal Como Fonte de Vida e Sade and AquaValorCentro de Valorizao e Transferncia de Tecnologia da gua (NORTE-01-0246-FEDER-000053), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)