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The imbalance between the production of ROS and the bodys defense against it leads to damage to lipids, proteins, and DNA in neurons

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Previous research has demonstrated that xCT serves a crucial role in ferroptosis in certain cell types such as F98, 143B, BjeHLT, BJeLR, Calu-1 and HT-1080 cells (87,111)

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Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC