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Biochem Mosc
doi: 10.1038/s41467-023-40579-1 75 RottenbergSDislerCPeregoP
Therefore, targeting the Keap1/Nrf2/HO-1 axis may be promising to sustain antioxidant stress and enhance therapeutic effects in cancer cells
Indirect evidence to support this adenoma-carcinoma sequence includes the following: 1) prevalence rates cosegregate within populations, 2) subsite distribution patterns within the colorectum are similar, 3) benign adenomatous tissue is often juxtaposed with invasive cancer in early- stage malignancies, and 4) incidence rates of CRC are decreased by endoscopic polypectomy
