Indeed, the combination of D + Q is more effective and allows to target more senescent cell types (compared to the use of each drug alone), by inhibiting the pro-survival pathways induced in senescent cells, notably in idiopathic pulmonary fibrosis (IPF) 10,11,12 , diabetes and chronic kidney disease 13 or Alzheimers disease 14
A study also found that adding cysteine to isolated cultured neurons from aged mice increased the cellular cysteine/cystine and increased mitochondrial NADH levels back to the levels present in young neurons ( + ]/[NADH], metabolic function may be enhanced, but the mechanism through which this occurs following cysteine administration remains unexplored
Transplant Direct [Internet]
Hu J, Zhang Y, Jiang X, Zhang H, Gao Z, Li Y, Fu R, Li L, Li J, Cui H, Gao N
doi:10.1126/science.6147899