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In addition, it simulates food transit times in the upper gut

Erythrocytes are enucleated cells with a cytoplasm without organelles and rich in hemoglobin (Hb), which represents about 95% of total erythrocytes cytoplasmic proteins [4, 5]

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Several studies analyzed the exo-metabolome in culture media to examine hepatotoxic effects of xenobiotics ( The analysis of the exometabolome is a valuable tool for evaluating drug-induced liver damage, particularly in cases where obtaining a liver sample from DILI patients is not feasible for medical and ethical reasons

Figure 7 Current research on ferroptosis in kidney diseases has predominantly focused on AKI and CKD, with accumulating evidence linking ferroptosis to interstitial fibrosis, mitochondrial dysfunction, inflammatory cell infiltration, and impaired tubular regeneration, key drivers of CKD progression (285, 286)