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Bilirubin oxidation was enhanced in the diseased skin of patients with AD and levels of the oxidized metabolite biopyrrin detected in urine correlated with the severity of AD ( 4 Manage oxidative stress in AD Immunity and inflammation are pivotal in the pathogenesis of AD

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13 Agarwal R, Katare OP, Vyas SP

In other cases, the cause is unknown (idiopathic), likely from a mix of genes, metabolism, and immune issues

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