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In mitochondria, treatment with H 2 O 2 rapidly, but in an indirect way, inactivates mitochondrial aconitase, an essential enzyme in the citric acid cycle ( 2 O 2 reaches the mitochondria comes from experiments that showed that the suppression of CAT in the peroxisome decreased the mitochondrial aconitase activity by 85% within 24 h (Walton and Pizzitelli, 2012)

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Activation of purified guanylate cyclase by nitric oxide requires heme