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Begin at 1 mg daily for the first 1-2 weeks to assess tolerance, then increase to 1.5-2 mg daily if well-tolerated

Psychiatry 22 , 418423 (2007)

203 , 204 , 205 , 206 , 207 Problems with smell typically precede cognitive and motor symptoms and may occur as a result of the accumulation of betaamyloid and hyperphosphorylated tau in olfactory regions of the brain

This process is significant in numerous biological and pathological contexts and is implicated in the onset and progression of a wide array of human diseases