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Pregnancy and breastfeeding are clear contraindications - we lack sufficient safety data on high-dose IV administration during these times

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Illustrative measurement scenarios not human or veterinary guidance

Outcomes depend on study design and experimental conditions

[252] Vaccine manufacturers have responded to the Omicron variant by developing bivalent COVID-19 vaccines, which include a component of the original virus strain to provide broad protection against COVID-19 and a component of the Omicron variant to provide better protection against COVID-19 caused by the Omicron variant