Vitamin B12 is a cofactor in synthesizing methionine, which is essential for protein formation.[ref] If you are deficient in B12 or folate for a long time, you can develop megaloblastic anemia
TLR4 activation may lead to ROS signaling via direct interaction between TLR4 and NADPH oxidase (Gill et al., 2010
Ayvaz H, Cabaroglu T, Akyildiz A, Pala CU, Temizkan R, Aam E, Ayvaz Z, Durazzo A, Lucarini M, Direito R, Diaconeasa Z (2023) Anthocyanins: metabolic digestion, bioavailability, therapeutic effects, current pharmaceutical/industrial use, and innovation potential
After another 24 hours, the amount decreases again
However, when comparing the changes between the two groups, the one assigned to the intervention, supplement demonstrated significant improvements in various scores of the parent-rated Vineland Adaptive Behavior Scales: adaptive behavior (p=0.03), socialization (p=0.03), maladaptive behavior (p=0.04) and internalizing (p=0.02)