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Although Pck1 expression was only mildly elevated, G6pc expression was markedly elevated in Insr P1195L/ +/HFD mice

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A 2019 proof-of-concept study in Human Reproduction (Romero-Ruiz et al.) provided the earlier human data: kisspeptin treatment induced gonadotropic responses and rescued ovulation in a subset of women with PMOS, demonstrating direct clinical translation from the animal work