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doi: 10.1016/j.neubiorev.2015.07.015 419 MissailidisDSanislavOAllanCYAnnesleySJFisherPR

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Slight clumping may occur

Ketone bodies and ketogenic diets may exert neuroprotective effects by enhancing anti-apoptotic and antioxidant defences (e.g., via inhibition of mPTP opening, mitochondrial ROS production, and caspase activation, and activation of SIRT1/2/3PGC1FOXO1/3a and ERK/CREB/eNOS pathways, with Nrf2 engagement), and by modulating NAD-dependent signalling and epigenetic/post-translational regulation (including HDAC/p300-mediated histone modifications) that can upregulate neurotrophic programs such as BDNF expression [69]

E.ArdiniM.et al (2018)