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Moreover, when they inhibited the expression, they observed a reduction in the production of type II collagen and aggrecan, main components of nucleus pulposus tissue

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The ensuing phagocytosis of RBCs may lead to iron overload within macrophages, which has been shown to cause progressive macrophage dysfunction, inflammatory M1 polarization, increased ferroptosis and exacerbated atherosclerosis 66,67,68,69,70,71