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According to the institutional review board (IRB) no formal research ethics approval or research and development approval was required as stipulated by the UK Policy Framework for Health and Social Care Research and the Health Research Authority decision tool

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[DOI] [PubMed] [Google Scholar] Zawada J

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Conversely, hypoxia and glucose deprivation in the brain promotes HDAC9 expression in endothelial cells, which has been associated to decreased expression of ZO-1, claudin-5, and occludin (Shi et al., 2016)

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Subsequent experiments compared hepatocytes treated with humanin in the presence or absence of AMPK silencing, providing important evidence regarding pathway dependency [1]

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