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Although cells benefit from low or moderate ROS levels, high ROS impose irreversible oxidative damage and so efficient ROS removal is necessary to maintain homeostasis 21,106 and controlled cellular activation

China Patent CN102559529 (B) Wang Y, Wang D, Wei G, Wang C (2013b) Improved co-production of S-adenosylmethionine and glutathione using citrate as an auxiliary energy substrate

(ii) the -ketoglutarate dehydrogenase complex that catalyzes the conversion of -ketoglutarate to succinyl CoA, another important intermediate of the citric acid cycle

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