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Genetic attenuation of PHGDH or SHMT2 and pharmacologic inhibition of PHGDH in human lung fibroblasts have shown that these enzymes are required for collagen synthesis downstream of TGF-

Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module

This study demonstrated that SAMe, as a dietary treatment, may operate in some circumstances to therapeutically boost methylation patterns to improve neurodevelopment

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Citrate synthase activity Tissues were homogenized with an electric potter in 50 mM phosphate buffer (pH, 7.5) at 4C and centrifuged at 600 g for 10 minutes, in the presence of protease inhibitor (1:100)