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Another key limitation is the poor bioavailability of some compounds, such as curcumin, which may restrict their clinical applicability despite strong preclinical efficacy

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The balance of N -deacetylase and N -acetylase in favor of the former in the guinea pig may contribute to the susceptibility of this species to 2,3,5-(triglutathion- S -yl)hydroquinone nephrotoxicity (Lau et al., 1995)

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