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Nutrition 26:112119 Kandil S, Brennan L, McBean GJ (2010) Glutathione depletion causes a JNK and p38 MAPK -mediated increase in expression of cystathionine--lyase and upregulation of the transsulfuration pathway in C6 glioma cells

To test whether these dimeric macrocycles behave as Met agonists, we first monitored phosphorylation of the Y1234/1235 residues in the activation loop of the Met tyrosine kinase domain

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Moreover, PEITC caused a rapid depletion of mGSH and a significant elevation of ROS and NO, induced a disruption of the mitochondrial electron transport complex I, and a significant suppression of mitochondrial respiration that resulted in cytotoxicity in leukemia cells ( As mGSH is regulated by cholesterol, as described above, the trafficking of mitochondrial cholesterol may modulate cancer cell biology