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Clin Microbiol Rev 12(4):501517 Podust LM, Poulos TL, Waterman MR (2001) Crystal structure of cytochrome P450 14-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

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Similarly, trametinib (a MEK inhibitor) enhances the transcription of ferritin heavy chain (FTH1) and ferritin light chain (FTL) and promotes ferritinophagy through NCOA4 while reducing ferroportin expression, thereby increasing intracellular iron levels and ultimately triggering ferroptosis in PDAC cells [22]

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Healthspan's Topical Rapamycin+ for Hair protocol is built around this multi-mechanism approach under clinical supervision