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Indeed, it has been observed that CD38 levels increase significantly during aging, with an increased consumption of NAD contributing to NAD reduction during aging

doi: 10.3389/fpsyt.2019.01016

found that Zicuiyin decoction reduced serum creatinine levels in patients with DKD, accompanied by an increased abundance of Prevotellaceae and Lactobacillaceae and a decreased abundance of Enterobacteriales, Clostridiaceae, and Micrococcaceae ( Table 3 ) [189]