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In parallel, non-microbiome strategies, including next-generation prokinetics, IVIG, G-POEM, SNS, and emerging antifibrotic agents, are expected to contribute meaningfully when integrated into phenotype-guided treatment algorithms

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A small percentage (20%) is derived from the catabolism of various hepatic hemoproteins (myoglobin, cytochrome P450) as well as from the overproduction of heme from ineffective erythropoiesis in the bone marrow

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