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The NHS schedule for treating B12 deficiency is a loading dose of 1mg hydroxocobalamin by intramuscular injection every two to three days for two weeks, then a maintenance dose every two to three months for life when the cause is non-dietary

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It is most relevant during GLP-1 use or caloric deficit, when fatigue is part of the picture, with age-related NAD+ decline, or when progress stalls after a clean first month

The deltoid typically recovers within three to five days, yet injuries involving deeper shoulder structures behave differently