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Metformin has also been shown to have an anti-depressant effect in a chronic-restraint stress model of depression in mice, which is blocked by genetic knockdown of hippocampal AMPK catalytic subunits ( Prkaa1 and Prkaa2 ) [136]

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Metabolism [edit] GABA transaminase enzymes catalyze the conversion of 4-aminobutanoic acid (GABA) and 2-oxoglutarate (-ketoglutarate) into succinic semialdehyde and glutamate

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