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For instance, a study has reported that melatonin could enhance the developmental potential of porcine oocyte-granulosa cell complexes derived from preantral follicles (90), while another research has showed that melatonin, combined with cyclic adenosine monophosphate (cAMP) modulators, could promote meiotic and developmental competence in porcine oocytes from early antral follicles during IVG and pre-maturation culture (91)

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Precautions: Avoid overuse to minimize inflammatory response