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These results suggest a link between GSH oxidation and Ero1 activity that, if not direct, could be through the reduction of non-native disulphides or members of the PDI family

Additionally, in a 30-day placebo-controlled trial in 300 adults (aged 18-65 years), supplementation with the B vitamins (at doses of about 3 to 13 times the RDA, excluding folic acid), vitamin C (1,000 mg/day), calcium (100 mg/day), and magnesium (100 mg/day) was associated with significant improvements in various scores of psychological stress compared to a placebo (139)

Goto, Y

Djanaguiraman M, Belliraj N, Bossmann SH, Prasad PVV

Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations