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Therefore, melatonin has a production rate proportional to the nocturnal noradrenergic stimulus, with minimum daytime and maximum nighttime values of up to 80%, and biosynthesis can be altered by artificial light [7]

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Synergy is predicted when the resulting IC 50 values for the combined drugs fall below the line connecting the two IC 50 points for each drug alone on the x- and y-axes

[PubMed: 19762782] 746

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