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Selenium Selenium is required for glutathione peroxidase activity and antioxidant defense

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Mechanistically, PA reduces the expression of GPX4 and heat shock factor 1 and regulates the transcription of genes related to iron metabolism (such as FTH, TFR1, and SLC40A1), causing iron homeostasis imbalance, while GPX4 overexpression reverses PA-induced ferroptosis in cardiomyocytes

J Physiol Pharmacol .201061(2)241-50

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