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Dysfunction of photoreceptors in dry AMD and Stargardt disease (SD) is associated with defects of atRAL clearance ( 2+ overload, tripeptide glutathione (GSH) depletion, damaged mitochondria and lipid peroxidation in photoreceptors via ACSL4 elevation, system Xc() inhibition and MT-CO2 activation, resulting in photoreceptor ferroptosis and dysfunction ( 2.2 Retinal degeneration induced by blue light or others Retinal photoreceptors, mainly including rod and cone cells, are a special type of neuroepithelial cells with light transduction ability with the function of converting light signals into neural signals (Zhao and Peng, 2021)

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