glutathione and methyl folate Use Functional Medicine To Address How MTHFR Impacts Your Body Amazon.com: GENEX Methyl Folate with

The existing evidence base comes from preclinical (animal) studies conducted primarily at Washington State University, where the compound was developed and patented for potential use in Alzheimer's disease

[9] Sun WD, et al

Importantly, a clinical study has demonstrated that combining radiotherapy with higher doses of the TGF-blocking antibody fresolimumab (10 mg/kg) increases overall survival significantly in metastatic breast cancer patients compared to those undergoing radiotherapy and receiving lower doses of fresolimumab (1 mg/kg) [135]

That 2kg difference is real but not dramatic

Modifying the phosphodiester backbone changes the metabolic pathway, improving nuclease-resistant stability, as seen with phosphorothioate linkages (108)