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81721003), the Guangdong Province Science & Technology Plan (2014B020228002), the National Key Basic Research and 973 Development Program of China (2015CB964600) and Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program

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Hydroxocobalamin is a prescription-only medicine (POM) that should be administered by appropriately trained healthcare professionals, typically following a standard regimen of loading doses (e.g., 1mg on alternate days for 1-2 weeks) followed by maintenance doses (1mg every 2-3 months, or every 2 months if neurological symptoms are present)

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