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In contrast, Ruminococcaceae UCG-009 was present in all experimental groups, and exhibited significantly greater relative abundance in both the LD control group and the 5A-1MQ-treated group switched from WD to LD compared to the WD control group (both significant before FDR correction

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This metabolic shift occurs due to the peptides action on the nicotinamide methylation pathway , which increases intracellular NAD+ availability, facilitating greater oxidative metabolism