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The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models
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Receptor-Binding Studies: Employed to evaluate peptide-receptor affinity, ligand specificity, and downstream signaling activation in receptor-focused research models
10.1126/science.289.5484.1567
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