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Nevertheless, there is a lack of the relevant cell lines to model the whole sophisticated cell interaction for both BBB and BCB, which is especially problematic for the latter since it is combined with a more model-challenging barrier geometry (Strazielle and Ghersi-Egea, 2011)

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Using conservative doses for reasonable durations with breaks between cycles represents a prudent approach to risk management

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Glutamine also contributes to maintaining normal intestinal and metabolic function and participates in pathways related to cellular repair and tissue maintenance