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PLoS One 10, e115699 (2015)

59,60 Specific genes implicated include vascular endothelial growth factor (VEGF), neurotrophic receptor tyrosine kinase 1, sodium voltage-gated channel alpha subunit 2 (SCN2A), angiotensin-converting enzyme, and methylenetetrahydrofolate reductase, with polymorphisms associated with increased DN susceptibility

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Physiologic GH replacement typically results in IGF-1 levels within or near the reference range, not the sustained high exposures that drive mitogenesis in vitro