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The recommended daily intake (RDI) of vitamin B12 for adults is 6 micrograms per day

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doi:10.1007/s00592-018-1240-x

Sigmoidal dose-response curves and reliable estimates of IC 50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 3)

They found that 9% had an outright deficiency and 16% exhibited a near deficiency. Many of these individuals were suffering from neurological symptoms (4)