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A high-affinity, saturable transport mechanism for DSIP at the blood-brain barrier was demonstrated in vascularly perfused guinea pig brain, with the highest unidirectional transfer rate in the hippocampus (Kin 1.66 L/min/g) [9]

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hypothalamus and brain stem nuclei), as well as regions involved in synaptic plasticity, memory, reward functions and emotional responses (Figure)

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