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In the case of excessive ROS production, other redox-sensitive systems are affected, such as expression of endothelial nitric oxide synthase (eNOS) (4)

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It is noteworthy that an excessive dietary intake of methionine-rich animal protein is an additional cause of hyperhomocysteinemia detected both in the fasting state and after an oral methionine load, especially when tissue folate and cobalamin stores are intact

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