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Subsequently, dopaquinone undergoes a series of redox reactions to produce dopachrome, which forms both DHI and DHICA, eventually yielding brown-black eumelanin

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On the other hand, surplus Fe 2+ induces the activation of ferric enzymes such as lipoxygenases (LOXs) and further promotes lipid peroxidation in cytomembrane, which eventually results in cell death[21]

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