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10.1038/jhg.2011.126 J

A compound that helps grow new vasculature into poorly perfused tissue is, at least in theory, aimed squarely at the root of the issue

Suppression of HIF-PH in cultured Drosophila melanogaster cells by RNA interference resulted in elevated expression of a hypoxia-inducible gene (encoding lactate dehydrogenase) under normoxic conditions, indicating that HIF-PH is an essential component of the pathway through which cells sense oxygen

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