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Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

However, in our patient, neither severe clinical symptoms, such as massive ascites or pleural effusion, nor abnormal blood test results were found

Subsequent investigations demonstrated that FSP1, regulated by Nrf2, significantly inhibited lung cancer cell growth and sensitised Keap1 -deficient cells to ferroptosis by knockdown or inhibition of FSP1 expression in Keap1 post-mutant lung cancer [46, 78]

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