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A progressive gradient in GM changes was also observed between healthy, constipated, prodromal PD (characterised by constipation, hyposmia and probable RBD) and PD individuals, showing a gradual decrease in total abundance of strict anaerobes with anti-inflammatory properties (including Roseburia inulinivorans , Roseburia intestinalis and Faecalibacterium prausnitzii ) [128]

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Arch Biochem Biophys 237:408414 Cadenas E, Boveris A, Ragan CI, Stoppani AO (1977) Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria