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5 Ketamine is thought to mitigate pain, at least partly, through its complex interaction with mu and kappa opioid receptors, although ketamine affinity for these receptors is almost tenfold less than for the NMDA channel

Jabr-Milane LS, van Vlerken LE, Yadav S, Amiji MM

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In some embodiments, the antioxidant or anti-apoptotic agent is Sodium Thiosulfate, Potassium Thiosulfate, HMTBa, Oltipraz, D-cysteine, D-methionine, or a combination thereof