For example, iPLA2 (PLA2G6), a Ca 2+ -independent PLA2, hydrolyzes 15-HpETE-phosphatidylethanolamine (PE) and was shown to suppress p53-driven ferroptosis following reactive oxygen species (ROS)-induced stress 18,19
doi: 10.3389/fmicb.2020.02075 184 WuX.ZhangS.LiH.ShenL.DongC.SunY.et al
The scavenging activity of antioxidants, such as polysaccharides, is investigated by their ability to suppress HO generation or clear formed radicals, particularly through electron-donating groups and iron-chelating mechanisms (Rumpf et al., 2023)
Collectively, this dual exhaustion effect significantly boosts OH production and improves therapeutic effect
PMID: 6715357, DOI: 10.1016/s0021-9258(18)91040-9