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This could trigger a positive feedback cycle whereby protein aggregates trigger the aggregation of other proteins in a chain reaction that eventually captures elements of the proteostatic mechanisms in place to counteract them

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Table 2 presents the summarized relevant studies on the connection between iodine and PPARs

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If triglycerides rise above 500 mg/dL on repeat testing, most guidelines recommend reducing the isotretinoin dose or temporarily stopping the drug until levels normalize